This article presents a comprehensive analysis of the circumstances surrounding the deaths of all U.S. presidents who have died. Based on historical documents, medical conclusions, and expert assessments, the chronology and causes of death of the nation’s leaders are reconstructed. Special attention is given to eight presidents who died in office, including four felled by assassins and four who died of natural causes. The statistical analysis covers natural mortality, assassinations, diseases concealed from the public, as well as unique historical coincidences related to the dates of the presidents’ deaths.